Vial products ship as dry lyophilized material unless the product format explicitly states otherwise.
10mL Vial99%+ PurityPerformance & Vitality
10mL Vial
Melanotan II
Melanocortin agonist — pigmentation research
$55.00
Volume pricing
Per-unit price drops automatically as quantity increases.
| Strength | 1 | 2+ | 5+ |
|---|---|---|---|
| 10mg | $55.00 | $52.25 | $49.50 |
Per-unit pricing at each quantity break, applied automatically at checkout.
Melanocortin agonist — pigmentation research
Lot documentation
Certificate of Analysis
Your lot number is stamped on the base of the vial or bottle. Match it to the list to open the certificate for the exact material you received.
- Lots on file
- 1
- Laboratory
- AxisPharm, LLC
What the literature reports
Melanotan-II is a cyclic alpha-MSH analog studied in early human pharmacology for melanotropic activity and incidental erectile responses, and later in dedicated erectile-function research.
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In a pilot phase I study, subcutaneous melanotan-II increased skin pigmentation and was associated with spontaneous penile erections in male volunteers.
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In men with psychogenic erectile dysfunction, melanotan-II initiated subjectively reported erections in a double-blind crossover study.
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Human studies with melanotan-II reported initiation of penile erection and changes in sexual motivation measures in controlled experimental settings.
These summaries describe findings reported in published laboratory and clinical literature about this compound. They are provided for research context only. They are not claims about this product, and nothing here describes an intended use in humans or animals. This material is supplied strictly for laboratory research use.
Technical documentation
About Melanotan II
Technical overview
Synthetic cyclic melanocortin receptor agonist
Melanotan II is a synthetic cyclic heptapeptide analogue of α-melanocyte-stimulating hormone. In research settings it is used to probe melanocortin receptors, especially MC1R-linked pigmentation pathways and central MC3R/MC4R circuits involved in sexual function and energy balance. It is investigational and is discussed here strictly as a research compound.
Small human pilot studies in the 1990s characterized subcutaneous dosing, pigmentation changes, and dose-limiting effects such as nausea and yawning/stretching complexes. Separate controlled work examined erectile responses in men with psychogenic erectile dysfunction. Those papers are historical clinical-research documents, not modern use guides.
Because Melanotan II sits in a compliance-sensitive category often misused in cosmetic tanning communities, educational content must stay inside research-use-only language. No cosmetic self-administration guidance is provided or implied.
Mechanism of action
Melanotan II is a non-selective melanocortin receptor agonist. MC1R activation on melanocytes increases eumelanin synthesis, which is why pigmentation endpoints appear in early trials. Central MC3R/MC4R engagement helps explain observed effects on sexual behavior and appetite-related readouts in experimental models. Cyclic structure improves potency and enzymatic stability versus linear native α-MSH fragments.
Research applications
- melanocortin receptor pharmacology
- pigmentation biology
- sexual function neuroendocrine research
- energy balance and appetite models
- peptide PK assay development
Fields of active investigation, not claims. Investigation is not proof.
Dermatology-adjacent pigment labs, melanocortin neuropharmacology groups, and sexual-medicine research units are the historical audiences. Regulatory, toxicology, and analytical chemists also study it because unregulated cosmetic channels created public-health surveillance questions. This profile is for research literacy only.
Amounts reported in the literature
What published research and laboratory protocols document. These describe what was studied — they are not instructions, recommendations, or a protocol for use.
| Reported amount | Frequency | Route | Research context |
|---|---|---|---|
| 700 mcg – 2.1 mg | weekday research dosing over short courses | subcutaneous | Pilot phase I subcutaneous research (Dorr et al.) |
| 1.75 mg | investigational single/short-term SC dosing | subcutaneous | Psychogenic ED pharmacodynamic study (Wessells et al.) |
Handling and storage
Store lyophilized Melanotan II frozen or refrigerated per COA, dry and light-protected. After bacteriostatic-water reconstitution, keep refrigerated and protected from light; discard according to lab stability policy.
Notes on combined research
Research literature more often studies Melanotan II alone as a melanocortin probe than as part of a modern peptide stack. Mechanistic comparisons are made with afamelanotide/Melanotan I (linear NDP-MSH) and with selective MC4R agonists used in metabolic or sexual-function research. No cosmetic stacking discussion is appropriate or provided.
Analytical specifications
| Purity | ≥99.3% by HPLC |
|---|---|
| Format | 10mL Vial |
| Physical form | Lyophilized powder |
| Third-party laboratory | AxisPharm, LLC |
| Lots with COA on file | 1 |
| Also referred to as | Melanotan-2, MT-II, MT2, Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2 |
| Reported half-life | Short plasma residence in rodent PK work (tens of minutes reported); biologic pigment effects outlast plasma levels |
Identity and purity are documented per lot on the Certificate of Analysis for the material you receive. Lot, manufacture and expiry are stamped on the base of the vial or bottle.
Frequently asked questions
What is the dosage for Melanotan 2 in published research?
Human pilot research commonly referenced about 0.025 mg/kg subcutaneously (on the order of 1–2 mg for many adult body weights) under clinical supervision. Those are historical trial exposures for research characterization only.
How much BAC water for Melanotan 2?
For a typical 10 mg research vial, 2–3 mL bacteriostatic water is a common laboratory dilution so that mcg/kg calculations are syringe-measurable. Exact volume is protocol-dependent.
Melanotan 2 dosage per day?
Early phase I designs used repeated weekday subcutaneous doses over about two weeks rather than an indefinite daily lifestyle schedule. Published human work is short-course and supervised.
Melanotan 2 dosage chart?
Research charts, when used, convert mg/kg trial doses into mcg for a stated body mass and diluent volume. They are literature translation tools, not tanning guides.
What is Melanotan 2 half life?
Rodent pharmacokinetic reports describe rapid plasma clearance, while pigmentation biology can continue after the peptide is no longer measurable in blood. Human half-life characterization remains limited compared with approved melanocortin drugs.
Can Melanotan 2 be stacked?
Controlled research generally evaluates it as a single melanocortin agonist. Combining research chemicals for cosmetic tanning is outside the scope of legitimate RUO education and is not advised here.
Is Melanotan II the same as afamelanotide?
No. Afamelanotide (Melanotan I / NDP-MSH) is a related but distinct linear analogue with a different clinical development path. Melanotan II is the cyclic heptapeptide MT-II.
Why is Melanotan II discussed as research-only?
It is not an FDA-approved tanning or sexual-function drug, and unsupervised cosmetic use has raised safety and quality concerns. Educational content therefore stays inside research-literature framing.
References
Every reference below resolves to an indexed paper. We would rather cite less and cite accurately.
- Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.
- Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study.
- A comparison of HPLC and bioassay methods for plasma melanotan-II (MT-II) determination: application to a pharmacokinetic study in rats.
Research use only
For laboratory and research purposes only. Not for human consumption, veterinary use, or medical applications. This product is not a drug, food, supplement or cosmetic, is not approved by the FDA, and is not intended to diagnose, treat, cure or prevent any disease. This page summarises published scientific literature; it is not medical advice and not a recommendation to use this compound. All handling must be performed by qualified personnel in a controlled laboratory environment.
Made in America. Documented lot by lot.
Most peptides sold in this category are imported in bulk, repackaged, and sold with no paperwork attached to the material in the bottle. Ours are synthesized in United States laboratories and every lot carries its own certificate.
Where is this material made?+
In United States laboratories. We buy from domestic synthesis rather than importing finished bulk from an overseas supplier and relabeling it. That is the reason we are able to name a specific laboratory, lot and test date for what you receive.
Why does a US laboratory matter?+
A domestic supply chain is shorter and documented end to end: identifiable facilities operating under US laboratory practice, and paperwork that follows one specific lot instead of a generic product description. It also means shorter transit and no repackaging between the laboratory and the customer.
What documentation comes with a lot?
A lot-specific Certificate of Analysis from an independent laboratory. The lot number is stamped on the base of the container — match it against the certificates listed on this page, or scan the QR code on the label, to open the report for the exact material shipped.
Where does my order ship from?+
Our United States facility, packed and dispatched domestically with tracking. Orders do not transit customs or get repackaged en route.
Pairs well with.
